Article
OLETF allele of hyperglycemic QTL Nidd3/of is dominant.
Experimental animals - 1 Apr 2008
Kose Hiroyuki, Yamada Takahisa, Matsumoto Kozo
Abstract excerpt
The OLETF rat is a well-established model for the study of type 2 diabetes associated with obesity and has been shown to possess multiple hyperglycemic alleles in its genome. Here we focused on and carefully characterized one of the previously reported congenic strains, F.O-Nidd3/of that carries the OLETF allele of the Nidd3/of locus (also known as Niddm21 in the Rat Genome Database) in the normoglycemic F344...
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