Article
Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 1999
Wei S, Wei K, Moralejo D H, Ogino T, Koike G, Jacob H J, Sugiura K, Sasaki Y, Yamada T, Matsumoto K
Abstract excerpt
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type, non-insulin-dependent diabetes mellitus (NIDDM) in humans. We have previously reported four quantitative trait loci (QTLs) responsible for NIDDM on Chromosomes (Chrs) 7, 14, 8, and 11 (Nidd1-4/of for Non-insulin-dependent diabetes1-4/oletf) by a whole-genome search in 160 F2 progenies obtained by mating the OLETF and the...
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