Article
Genetic analysis of non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat.
Biochemical and biophysical research communications - 8 Dec 1997
Nara Y, Gao M, Ikeda K, Sato T, Sawamura M, Kawano K, Yamori Y
Abstract excerpt
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese NIDDM. We performed a genome wide scan in F2 progenies obtained by crossing OLETF rats with two control strains, Long-Evans Tokushima Otsuka (LETO) and Fisher-344(F-344) rats. Since diabetes develops only in male proge...
Topics
- Animals
- Blood Glucose
- Chromosome Mapping
- Crosses, Genetic
- Cytochrome P-450 CYP11B2
- Diabetes Mellitus
- Diabetes Mellitus, Type 2
- Female
- Genetic Linkage
- Genetic Markers
- Genomic Imprinting
- Genotype
- Hyperglycemia
- Male
- Obesity
- Postprandial Period
- Rats
- Rats, Inbred F344