Article
Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats.
Genomics - 15 Dec 1999
Okuno S, Watanabe T K, Ono T, Yamasaki Y, Goto Y, Miyao H, Asai T, Kanemoto N, Oga K, Mizoguchi-Miyakita A, Takagi T, Takahashi E, Nakamura Y, Tanigami A
Abstract excerpt
Altered lipid metabolism is closely associated with diabetes in humans, although predisposing genetic factors that affect hyperlipidemia have not yet been clarified. Our previously established OLETF strain is an obese rat model of type II diabetes, exhibiting hypertriglycemia as well as hyperinsulinemia, hyperglycemia, insulin resistance, and abundant abdominal fat. To identify genetic factors responsible for...
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