Article
Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 1999
Sugiura K, Miyake T, Taniguchi Y, Yamada T, Moralejo D H, Wei S, Wei K, Sasaki Y, Matsumoto K
Abstract excerpt
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type, non-insulin-dependent diabetes mellitus (NIDDM) in humans. We have previously identified 11 quantitative trait loci (QTLs) responsible for NIDDM susceptibility on Chromosomes (Chrs) 1, 5, 7, 8, 9, 11, 12, 14, and 16 (Nidd1-11/of for Non-insulin-dependent diabetes 1-11/oletf) by using the interval mapping method in 160 F(2)...
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