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Article

Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB.

Molecular and cellular biology - 1 Sept 2000

Barndt R J, Dai M, Zhuang Y

Abstract excerpt

Lymphocyte development and differentiation are regulated by the basic helix-loop-helix (bHLH) transcription factors encoded by the E2A and HEB genes. These bHLH proteins bind to E-box enhancers in the form of homodimers or heterodimers and, consequently, activate transcription of the target genes. E2A homodimers are the predominant bHLH proteins present in B-lineage cells and are shown genetically to play...

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Share to DNA Nucleotidyltransferases
Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Helix-Loop-Helix Motifs

Share to Hematopoiesis

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to TCF Transcription Factors

Share to Thymus Gland

Share to VDJ Recombinases

Source

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Identifiers

PMID: 10958665
DOI: 10.1128/MCB.20.18.6677-6685.2000
PMCID: PMC86175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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