Article
Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes.
Development (Cambridge, England) - 1 Jun 1998
Dean W, Bowden L, Aitchison A, Klose J, Moore T, Meneses J J, Reik W, Feil R
Abstract excerpt
In vitro manipulation of preimplantation mammalian embryos can influence differentiation and growth at later stages of development. In the mouse, culture of embryonic stem (ES) cells affects their totipotency and may give rise to fetal abnormalities. To investigate whether this is associated with...
Topics
- Alleles
- Animals
- Chimera
- DNA Methylation
- Embryonic and Fetal Development
- Female
- Fetus
- Gene Expression Regulation, Developmental
- Genomic Imprinting
- Insulin-Like Growth Factor II
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Muscle Proteins
- Nerve Tissue Proteins
- Nuclear Proteins
- Phenotype