Article
Role for DNA methylation in genomic imprinting.
Nature - 25 Nov 1993
Li E, Beard C, Jaenisch R
Abstract excerpt
The paternal and maternal genomes are not equivalent and both are required for mammalian development. The difference between the parental genomes is believed to be due to gamete-specific differential modification, a process known as genomic imprinting. The study of transgene methylation has shown that methylation patterns can be inherited in a parent-of-origin-specific manner, suggesting that DNA methylation may...
Topics
- Alleles
- Animals
- DNA
- DNA Modification Methylases
- Embryonic and Fetal Development
- Female
- Gene Expression Regulation
- Homozygote
- Male
- Methylation
- Mice
- Mice, Mutant Strains