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Article

Disruption of imprinting in cloned mouse fetuses from embryonic stem cells

1 Oct 2003

Abstract excerpt

Cloned mice typically display abnormal development, such as overgrowth of fetuses and placentae. Quantitative expression analysis of eight imprinted genes (H19, Igf2, Igf2r, Air, Peg1/Mest, Peg3, Nuronatin (Nnat) and Ndn) and an alternate transcript of Igf2 (P0) in embryonic stem cloned fetuses and placentae at days 9.5, 12.5 and 17.5 after mating was carried out by real time PCR to investigate whether epigenetic...

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PMID: 14525537
DOI: 10.1530/rep.0.1260549

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