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Modulation of imprinted gene network in placenta results in normal development of in vitro manipulated mouse embryos

11 Feb 2010

Abstract excerpt

Genomic imprinting regulates the expression of a group of genes monoallelically expressed in a parent-of-origin specific manner. Allele-specific DNA methylation occurs at differentially methylated regions (DMRs) of these genes. We have previously shown that in vitro fertilization and embryo culture result in methylation defects at the imprinted H19-Igf2 locus at the blastocyst stage. The current study was...

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PMID: 20150233
DOI: 10.1093/hmg/ddq059

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