Article
Mutations synthetically lethal with cep1 target S. cerevisiae kinetochore components.
Genetics - 1 May 1998
Baker R E, Harris K, Zhang K
Abstract excerpt
CP1 (encoded by CEP1) is a Saccharomyces cerevisiae chromatin protein that binds a DNA element conserved in centromeres and in the 5'-flanking DNA of methionine biosynthetic (MET) genes. Strains lacking CP1 are defective in chromosome segregation and MET gene transcription, leading to the hypothe...
Topics
- Amino Acid Sequence
- Base Sequence
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Chromatin
- Chromosomal Proteins, Non-Histone
- DNA-Binding Proteins
- Fungal Proteins
- Genes, Lethal
- Helix-Loop-Helix Motifs
- Humans
- Kinetochores
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Open Reading Frames
- RNA, Messenger
- RNA-Binding Proteins
- Saccharomyces cerevisiae