Article
A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1).
Genes & development - 1 Apr 1991
Shero J H, Hieter P
Abstract excerpt
A new approach to identify genes involved in Saccharomyces cerevisiae kinetochore function is discussed. A genetic screen was designed to recover extragenic dosage suppressors of a CEN DNA mutation. This method identified two suppressors, designated MCK1 and CMS2. Increased dosage of MCK1 specifically suppressed two similar CEN DNA mutations in CDEIII, but not comparably defective CEN DNA mutations in CDEI or...
Topics
- Amino Acid Sequence
- Base Sequence
- Benomyl
- Centromere
- Chromosomes, Fungal
- DNA, Fungal
- Genes, Fungal
- Genes, Suppressor
- Genotype
- Glycogen Synthase Kinase 3
- Molecular Sequence Data
- Mutation