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Article

Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.

PloS one - 28 Oct 2009

Pagliuca Cinzia, Draviam Viji M, Marco Eugenio, Sorger Peter K, De Wulf Peter

Abstract excerpt

BACKGROUND: Kinetochores attach sister chromatids to microtubules of the mitotic spindle and orchestrate chromosome disjunction at anaphase. Although S. cerevisiae has the simplest known kinetochores, they nonetheless contain approximately 70 subunits that assemble on centromeric DNA in a hierarchical manner. Developing an accurate picture of the DNA-binding, linker and microtubule-binding layers of kinetochores,...

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Identifiers

PMID: 19893618
DOI: 10.1371/journal.pone.0007640
PMCID: PMC2764089

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