Article
Expression of genes related to the human erbB, erbA, pdgf and pdgf-r in tumors of different etiology in Xiphophorus.
International journal of cancer - 19 Aug 1992
Zechel C, Peters H, Schleenbecker U, Anders F
Abstract excerpt
The melanoma determining Tu locus of the teleost Xiphophorus contains an accessory gene, x-erbB*a, which is closely related to the EGF receptor gene family, and is probably oncogenic. x-erbB*a exists in allelic forms that are specific for distinct Tu-loci, and shows high homology to a non-allelic non-oncogenic counterpart x-erbB*i which is transcribed into mRNA of 4.6 kb in non-tumorous and tumorous tissues of...
Topics
- Alleles
- Animals
- ErbB Receptors
- Fish Diseases
- Fishes
- Gene Expression
- Melanoma
- Neoplasms
- Platelet-Derived Growth Factor
- Proto-Oncogene Proteins
- Proto-Oncogenes
