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Article

Superagonistic behaviour of epidermal growth factor/transforming growth factor-alpha chimaeras: correlation with receptor routing after ligand-induced internalization.

The Biochemical journal - 1 Nov 1997

Lenferink A E, Kramer R H, van Vugt M J, Königswieser M, Di Fiore P P, van Zoelen E J, van de Poll M L

Abstract excerpt

Human epidermal growth factor (EGF) and human transforming growth factor alpha (TGF-alpha) are structurally related polypeptide growth factors that exert their mitogenic activity through interaction with a common cell-surface receptor, the epidermal growth factor receptor (EGFR). The biological effect induced by these two ligands is quantitatively similar in most cases; in some test systems, however, TGF-alpha...

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Source

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Identifiers

PMID: 9581567
DOI: 10.1042/bj3270859
PMCID: PMC1218868

Genes

EGF
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Superagonistic behaviour of epidermal growth factor/transforming growth factor-alpha chimaeras: correlation with receptor routing after ligand-induced internalization.PMID 9581567Read ↗

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