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Article

A ligand-inducible epidermal growth factor receptor/anaplastic lymphoma kinase chimera promotes mitogenesis and transforming properties in 3T3 cells.

The Journal of biological chemistry - 21 Jun 2002

Piccinini Gina, Bacchiocchi Roberta, Serresi Michela, Vivani Caterina, Rossetti Silvia, Gennaretti Claudia, Carbonari Damiano, Fazioli Francesca

Abstract excerpt

Oncogenic rearrangements of the anaplastic lymphoma kinase (ALK) gene, encoding a receptor type tyrosine kinase, are frequently associated with anaplastic large cell lymphomas. Such rearrangements juxtapose the intracellular domain of ALK to 5'-end sequences belonging to different genes and create transforming fusion proteins. To understand how the oncogenic versions of ALK contribute to lymphomagenesis, it is...

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Source

Identifiers

PMID: 11919185
DOI: 10.1074/jbc.M111145200

Genes

ALK
EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A ligand-inducible epidermal growth factor receptor/anaplastic lymphoma kinase chimera promotes mitogenesis and transforming properties in 3T3 cells.PMID 11919185Read ↗

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Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity.Semantic proximity Read ↗

erbB-2 autophosphorylation is required for mitogenic action and high-affinity substrate coupling.Semantic proximity Read ↗

Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity.Semantic proximity Read ↗

A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling.Semantic proximity Read ↗

Determinants for transformation induced by the Axl receptor tyrosine kinase.Semantic proximity Read ↗

Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation.Semantic proximity Read ↗

ALK-activating homologous mutations in LTK induce cellular transformation.Semantic proximity Read ↗

Expression and functional analysis of the anaplastic lymphoma kinase (<i>ALK</i>) gene in tumor cell linesSemantic proximity Read ↗

Epidermal growth factor contains both positive and negative determinants for interaction with ErbB-2/ErbB-3 heterodimers.Semantic proximity Read ↗

The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction.Semantic proximity Read ↗

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