Article
Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction.
The Journal of biological chemistry - 3 Mar 1995
French A R, Tadaki D K, Niyogi S K, Lauffenburger D A
Abstract excerpt
Using members of the epidermal growth factor (EGF) family as well as site-directed recombinant human EGF mutants, we investigated how ligand binding properties influence endosomal sorting. Mouse EGF (mEGF), human EGF (hEGF), and transforming growth factor alpha (TGF alpha) bind to the human EGF r...
Topics
- Animals
- Biological Transport
- Epidermal Growth Factor
- ErbB Receptors
- Humans
- Hydrogen-Ion Concentration
- Hydrolysis
- Kinetics
- Ligands
- Mice
- Mutation
- Protein Binding
- Transforming Growth Factor alpha