Article
Ligand depletion negatively controls the mitogenic activity of epidermal growth factor.
Experimental cell research - 1 Apr 2005
van de Poll Monique L M, van Rotterdam Walter, Gadellaa Mireille M, Jacobs-Oomen Saskia, van Zoelen Everardus J J
Abstract excerpt
EGF activates the ErbB1 receptor, but there appears only a limited correlation between its receptor binding affinity and mitogenic activity. This is indicated by our present observation that in cells with high ErbB1 expression, including SUM102 breast tumor cells, low affinity EGF/Notch chimeras have similarly high mitogenic activity as EGF, in spite of the fact that EGF is superior in inducing receptor tyrosine...
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