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Article

Engineering epidermal growth factor for enhanced mitogenic potency.

Nature biotechnology - 1 Dec 1996

Reddy C C, Niyogi S K, Wells A, Wiley H S, Lauffenburger D A

Abstract excerpt

Successful use of growth factors in therapeutic and bioprocessing applications requires overcoming two attenuation mechanisms: growth factor depletion and receptor down-regulation. Current ameliorative strategies use physiologically inappropriate high growth-factor concentrations, along with periodic media refeeding in vitro and reinjection or controlled-release devices in vivo. We demonstrate a new approach...

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Identifiers

PMID: 9634854
DOI: 10.1038/nbt1296-1696

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Engineering epidermal growth factor for enhanced mitogenic potency.PMID 9634854Read ↗

Ligand depletion negatively controls the mitogenic activity of epidermal growth factor.Semantic proximity Read ↗

Discovery of improved EGF agonists using a novel in vitro screening platform.Semantic proximity Read ↗

Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction.Semantic proximity Read ↗

Superagonistic behaviour of epidermal growth factor/transforming growth factor-alpha chimaeras: correlation with receptor routing after ligand-induced internalization.Semantic proximity Read ↗

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.Semantic proximity Read ↗

Growth factors and growth factor gene therapies for treating chronic woundsSemantic proximity Read ↗

Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation.Semantic proximity Read ↗

Ligand-induced transformation by a noninternalizing epidermal growth factor receptor.Semantic proximity Read ↗

The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface.Semantic proximity Read ↗

A negative feedback loop attenuates EGF-induced morphological changes.Semantic proximity Read ↗

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Epidermal Growth Factor Receptor Expression in the Corneal EpitheliumSemantic proximity Read ↗

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