Article
Analogs of human epidermal growth factor which partially inhibit the growth factor-dependent protein-tyrosine kinase activity of the epidermal growth factor receptor.
FEBS letters - 7 May 1990
Matsunami R K, Campion S R, Niyogi S K, Stevens A
Abstract excerpt
Three site-directed mutants of human epidermal growth factor, Leu-26----Gly, Leu-47----Ala, and Ile-23----Thr, were examined for their ability to stimulate the protein-tyrosine kinase activity of the epidermal growth factor receptor. The receptor binding affinities of the mutant growth factors we...
Topics
- Binding, Competitive
- Cell Line
- Cell Membrane
- Epidermal Growth Factor
- ErbB Receptors
- Humans
- Kinetics
- Mutation
- Protein-Tyrosine Kinases