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Article

pH-dependent receptor/ligand dissociation as a determining factor for intracellular sorting of ligands for epidermal growth factor receptors in rat hepatocytes.

Journal of controlled release : official journal of the Controlled Release Society - 18 Jul 2002

Maeda Kazuya, Kato Yukio, Sugiyama Yuichi

Abstract excerpt

Both epidermal growth factor (EGF) and transforming growth factor-alpha (TGF alpha) bind to EGF receptors and TGF alpha has been reported to be more potent than EGF as far as many biological effects are concerned. One possible reason for this is thought to be the difference in their dissociation from the receptors in intracellular acidic compartments, which may affect the final pathway (lysosomal degradation or...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12106978
DOI: 10.1016/s0168-3659(02)00126-8

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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pH-dependent receptor/ligand dissociation as a determining factor for intracellular sorting of ligands for epidermal growth factor receptors in rat hepatocytes.PMID 12106978Read ↗

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