Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.

doi:10.1006/jmbi.1998.1669

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Article

Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.

Journal of molecular biology - 17 Apr 1998

Clackson T, Ultsch M H, Wells J A, de Vos A M

Abstract excerpt

The designed G120R mutant of human growth hormone (hGH) is an antagonist and can bind only one molecule of the growth hormone receptor. We have determined the crystal structure of the 1:1 complex between this mutant and the receptor extracellular domain (hGHbp) at 2.6 A resolution, and used it to...

Topics

Binding Sites
Crystallography, X-Ray
Epitopes
Human Growth Hormone
Humans
Kinetics
Models, Molecular
Mutation
Protein Binding
Protein Conformation
Receptors, Somatotropin
Tryptophan

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