Crystals of human growth hormone-receptor complexes. Extracellular domains of the growth hormone and prolactin receptors and a hormone mutant designed to prevent receptor dimerization.

doi:10.1006/jmbi.1993.1359

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Article

Crystals of human growth hormone-receptor complexes. Extracellular domains of the growth hormone and prolactin receptors and a hormone mutant designed to prevent receptor dimerization.

Journal of molecular biology - 20 Jun 1993

Ultsch M, de Vos A M

Abstract excerpt

A single-site human growth hormone mutant (hGH[G120R]), which inhibits receptor dimerization, was used to produce single crystals, suitable for high-resolution diffraction studies, of 1:1 complexes with the ligand-binding domain of the growth hormone receptor (hGHbp) and of the prolactin receptor...

Topics

Crystallization
Crystallography
Growth Hormone
Mutation
Protein Conformation
Receptors, Prolactin
Receptors, Somatotropin
Recombinant Proteins

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