Article
Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization.
Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003
Bernat Bryan, Pal Gabor, Sun Miao, Kossiakoff Anthony A
Abstract excerpt
Signaling in the human growth hormone (hGH)-human GH receptor system is initiated by a controlled sequential two-step hormone-induced dimerization of two hGH receptors via their extracellular domains (ECDs). Little is currently known about the energetics governing the important regulatory step in receptor signaling (step 2) because of previously existing experimental barriers in characterizing the binding of the...
Topics
- Alanine
- Binding Sites
- Biophysical Phenomena
- Biophysics
- Dimerization
- Escherichia coli
- Hormones
- Human Growth Hormone
- Humans
- Kinetics
- Models, Molecular
- Mutagenesis
- Mutation
- Protein Binding