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Article

The crystal structure of affinity-matured human growth hormone at 2 A resolution.

Journal of molecular biology - 11 Feb 1994

Ultsch M H, Somers W, Kossiakoff A A, de Vos A M

Abstract excerpt

A variant of human growth hormone (hGH), in which 15 mutations were introduced with phage display mutagenesis to improve receptor binding affinity by 400-fold, yielded two related crystal forms diffracting to high resolution. The structure of this variant was determined in both crystal forms, one at 2.0 A resolution and one at 2.4 A resolution, using molecular replacement with wild-type hGH taken from the...

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Identifiers

PMID: 8107110
DOI: 10.1006/jmbi.1994.1135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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