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Article

Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization.

Protein science : a publication of the Protein Society - 1 Sept 2003

Walsh Scott T R, Jevitts Liz M, Sylvester Juliesta E, Kossiakoff Anthony A

Abstract excerpt

Receptor signaling in the growth hormone (GH)-growth hormone receptor (GHR) system is controlled through a sequential two-step hormone-induced dimerization of two copies of the extracellular domain (ECD) of the receptor. The regulatory step of this process is the binding of the second ECD (ECD2) to the stable preassociated 1 : 1 GH/ECD1 complex on the cell surface. To determine the energetics that governs this...

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Source

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Identifiers

PMID: 12930995
DOI: 10.1110/ps.03133903
PMCID: PMC2323993

Genes

ECD
GHR
SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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