Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dose and time dependence of the cellular phenotype in rat hepatic preneoplasia and neoplasia induced by continuous oral exposure to N-nitrosomorpholine.

Carcinogenesis - 1 Jun 1994

Weber E, Bannasch P

Abstract excerpt

The dose and time dependence of the cellular phenotype in preneoplastic and neoplastic liver lesions was evaluated quantitatively in groups of male Sprague-Dawley rats continuously exposed to 0, 6, 12 and 24 mg/kg body wt of N-nitrosomorpholine (NNM) and studied at different time points up to 80,...

Topics

Administration, Oral
Animals
Dose-Response Relationship, Drug
Liver
Liver Neoplasms, Experimental
Male
Nitrosamines
Phenotype
Precancerous Conditions
Rats
Rats, Sprague-Dawley
Time Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8020161
DOI: 10.1093/carcin/15.6.1235

Genes

FAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8020161-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dose and time dependence of the cellular phenotype in rat hepatic preneoplasia and neoplasia induced by continuous oral exposure to N-nitrosomorpholine.PMID 8020161Read ↗

Cell proliferation and cell death (apoptosis) in hepatic preneoplasia and neoplasia are closely related to phenotypic cellular diversity and instability.Semantic proximity Read ↗

Effects of low doses of N-nitrosomorpholine on the development of early stages of hepatocarcinogenesis.Semantic proximity Read ↗

Enhancement and phenotypic modulation of N-nitrosomorpholine-induced hepatocarcinogenesis by dehydroepiandrosterone.Semantic proximity Read ↗

Significance of Hepatic Preneoplasia in Risk Identification and Early Detection of Neoplasia *Semantic proximity Read ↗

Number of simultaneously expressed enzyme alterations correlates with progression of N-ethyl-N-hydroxyethylnitrosamine-induced hepatocarcinogenesis in rats.Semantic proximity Read ↗

DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion.Semantic proximity Read ↗

Use of early phenotypic in vivo markers to assess human relevance of an unusual rodent non-genotoxic carcinogen in vitro.Semantic proximity Read ↗

Ultrasonographic evidence of phenotypic instability during hepatocarcinogenesis in N-nitrosomorpholine-treated rats.Semantic proximity Read ↗

Ultrastructural appearances of preneoplastic liver nodules induced through sequential treatment in rats.Semantic proximity Read ↗

Initiated rat hepatocytes in primary culture: a novel tool to study alterations in growth control during the first stage of carcinogenesis.Semantic proximity Read ↗

Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver.Semantic proximity Read ↗

Biochemical markers associated with the stages of promotion and progression during hepatocarcinogenesis in the rat.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.