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Article

Phenotypic properties of liver tumors induced by dehydroepiandrosterone in F-344 rats.

Japanese journal of cancer research : Gann - 1 Nov 1992

Rao M S, Subbarao V, Kumar S, Yeldandi A V, Reddy J K

Abstract excerpt

Dehydroepiandrosterone (DHEA), a C19 adrenal steroid hormone, induces peroxisome proliferation in liver cells and is hepatocarcinogenic in the rat. The present study deals with the phenotypic properties of DHEA-induced liver lesions. A majority of the altered areas (80-87%), neoplastic nodules (> 94%) and hepatocellular carcinomas (HCC, 80-100%) lacked the marker enzymes gamma-glutamyltranspeptidase and placental...

Topics

Animals
Blotting, Northern
Carcinogens
Carcinoma, Hepatocellular
Dehydroepiandrosterone
Histocytochemistry
Liver Neoplasms, Experimental
Male
Microbodies
Phenotype
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Rats, Inbred F344

Source

Open in PubMed Open full text

Identifiers

PMID: 1336491
DOI: 10.1111/j.1349-7006.1992.tb02742.x
PMCID: PMC5918701

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1336491-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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