Article
Effects of low doses of N-nitrosomorpholine on the development of early stages of hepatocarcinogenesis.
Carcinogenesis - 1 Jul 1995
Enzmann H, Zerban H, Kopp-Schneider A, Löser E, Bannach P
Abstract excerpt
Male Sprague-Dawley rats received the hepatocarcinogen N-nitrosomorpholine (NNM) in the drinking water at low dose levels ranging from 6 mg/l to 60 mg/l for 6 and 12 weeks, respectively. Foci of altered hepatocytes (FAH) were demonstrated histochemically using changes in the activities of glucose-6-phosphate dehydrogenase and glycogen phosphorylase, and in the glycogen content as markers. Proliferating cells were...
Topics
- Animals
- Carcinogens
- Cell Division
- Dose-Response Relationship, Drug
- Liver
- Liver Glycogen
- Liver Neoplasms, Experimental
- Male
- Nitrosamines
- Phenotype
- Precancerous Conditions