Cell proliferation and cell death (apoptosis) in hepatic preneoplasia and neoplasia are closely related to phenotypic cellular diversity and instability.

doi:10.1093/carcin/15.11.2467

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Article

Cell proliferation and cell death (apoptosis) in hepatic preneoplasia and neoplasia are closely related to phenotypic cellular diversity and instability.

Carcinogenesis - 1 Nov 1994

Zerban H, Radig S, Kopp-Schneider A, Bannasch P

Abstract excerpt

Preneoplastic and neoplastic hepatic lesions were induced in male Sprague-Dawley rats by oral exposure to N-nitrosomorpholine (12 mg/kg body wt/day) for 7 weeks (stop model). Twelve, 23 and 34 weeks after withdrawal of the carcinogen, cell proliferation and cell death (apoptosis) were studied in...

Topics

Animals
Apoptosis
Cell Division
Liver Glycogen
Liver Neoplasms, Experimental
Male
Nitrosamines
Phenotype
Precancerous Conditions
Rats
Rats, Sprague-Dawley
Thymidine

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