Article
Ultrasonographic evidence of phenotypic instability during hepatocarcinogenesis in N-nitrosomorpholine-treated rats.
Experimental and molecular pathology - 1 Aug 2002
Oh Jong-Young, Jeong Jin-Sook, Kim Yu-jin, Nam Kyoung-Jin, Park Byung-Ho, Kwon Eun-Young, Kim Young-Hoon, Hwang Tae-Ho
Abstract excerpt
Carcinogen-induced hepatoma in immunocompetent animal models has shown a progress similar to the clinical course of human hepatoma. Ultrasonography (US) was used for consecutive evaluation of the phenotypic changes in Sprague-Dawley rats exposed for 8 weeks to N-nitrosomorpholine (NNM, 200 mg/L). Three distinctive US findings were ascites, coarseness (defined as small and heterogeneously widespread increased...
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