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Article

3' splice site recognition in S. cerevisiae does not require base pairing with U1 snRNA.

Cell - 21 May 1993

Séraphin B, Kandels-Lewis S

Abstract excerpt

The conserved nucleotides 9 and 10 of U1 small nuclear RNA (snRNA) have been proposed to base pair with either 5' exon or 3' splice site sequences. In S. pombe, U1 snRNA pairing with the conserved 3' splice site is required for the first step of splicing and viability. In contrast, we show that S. cerevisiae U1 mutants at positions 9 and 10 are fully functional. Splicing of several genes is normal in these...

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PMID: 8500172
DOI: 10.1016/0092-8674(93)90258-r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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