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Article

Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice.

Molecular and cellular endocrinology - 5 Mar 2016

González-Mariscal Isabel, Krzysik-Walker Susan M, Kim Wook, Rouse Michael, Egan Josephine M

Abstract excerpt

The cannabinoid 1 receptor (CB1) is an important regulator of energy metabolism. Reports of in vivo and in vitro studies give conflicting results regarding its role in insulin secretion, possibly due to circulatory factors, such as incretins. We hypothesized that this receptor may be a regulator of the entero-insular axis. We found that despite lower food consumption and lower body weight postprandial GLP-1...

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Source

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Identifiers

PMID: 26724516
DOI: 10.1016/j.mce.2015.12.015
PMCID: PMC4752920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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