Article
Spontaneous mutations in lacI-containing lambda lysogens derived from transgenic mice: the observed patterns differ in liver and spleen.
Mutation research - 1 Nov 1994
Knöll A, Jacobson D P, Kretz P L, Lundberg K S, Short J M, Sommer S S
Abstract excerpt
The pattern of somatic mutation observed in tumor suppressor genes, such as the p53 gene, vary dramatically with tumor type. Some of the observed differences are due to tissue specific effects of mutagens, but it is also possible that some differences may reflect the tissue/cell type specificity...
Topics
- Animals
- Bacterial Proteins
- Bacteriophage lambda
- Base Sequence
- DNA
- Escherichia coli Proteins
- Genetic Vectors
- Lac Repressors
- Liver
- Lysogeny
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Repressor Proteins
- Spleen