Article
Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice.
Genetics - 1 Mar 2000
Stuart G R, Oda Y, de Boer J G, Glickman B W
Abstract excerpt
Mutation frequency and specificity were determined as a function of age in nuclear DNA from liver, bladder, and brain of Big Blue lacI transgenic mice aged 1.5-25 months. Mutations accumulated with age in liver and accumulated more rapidly in bladder. In the brain a small initial increase in mutation frequency was observed in young animals; however, no further increase was observed in adult mice. To investigate...
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