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Spontaneous mutation of the lacI transgene in rodents: absence of species, strain, and insertion-site influence.

Environmental and molecular mutagenesis - 1 Jan 2001

Zhang S, Glickman B W, de Boer J G

Abstract excerpt

Comparison of spontaneous mutation spectra derived from different transgenic constructs can provide valuable insights for interpreting the mechanisms of spontaneous mutation. In this study, spontaneous mutation frequencies and spectra of the lacI transgene are compared in the liver of C57BL/6, B6C3F1, and BC-1 mice and F344 rats. Before correction for clonal expansion, the mutant frequency varied from 2.6 +/-...

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PMID: 11246220
DOI: 10.1002/em.1021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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