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Article

Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis.

European journal of immunology - 1 Apr 1998

Sahrbacher U C, Lechner F, Eugster H P, Frei K, Lassmann H, Fontana A

Abstract excerpt

Nitric oxide (NO) generated by the inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). In this study mice genetically deficient for iNOS are shown to be susceptible to EAE induced by immunization with myelin oligodendr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9565373
DOI: 10.1002/(SICI)1521-4141(199804)28:04<1332::AID-IMMU1332>3.0.CO;2-G

Genes

MOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9565373-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis.PMID 9565373Read ↗

Experimental Autoimmune Encephalomyelitis Is Exacerbated in Mice Lacking the <i>NOS2</i> GeneSemantic proximity Read ↗

Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice.Semantic proximity Read ↗

Nitric oxide is a potential down-regulating molecule in autoimmune disease: inhibition of nitric oxide production renders PVG rats highly susceptible to EAE.Semantic proximity Read ↗

Disruption of NMDA Receptors in Oligodendroglial Lineage Cells Does Not Alter Their Susceptibility to Experimental Autoimmune Encephalomyelitis or Their Normal DevelopmentSemantic proximity Read ↗

Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice.Semantic proximity Read ↗

Mice lacking the gene for inducible or endothelial nitric oxide are resistant to sporocyst induced Sarcocystis neurona infections.Semantic proximity Read ↗

iNOS-mediated secondary inflammatory response differs between rat strains following experimental brain contusion.Semantic proximity Read ↗

Tissue expression of inducible nitric oxide synthase requires IFN-gamma production by infiltrating splenic T cells: more evidence for immunosuppression by nitric oxide.Semantic proximity Read ↗

Impaired vascular function in normoglycemic mice prone to autoimmune diabetes: role of nitric oxide.Semantic proximity Read ↗

Mice lacking inducible nitric oxide synthase develop spontaneous hypercholesterolaemia and aortic atheromas.Semantic proximity Read ↗

Inhibition of inducible nitric oxide synthase exacerbates chronic cerebral toxoplasmosis in Toxoplasma gondii-susceptible C57BL/6 mice but does not reactivate the latent disease in T. gondii-resistant BALB/c mice.Semantic proximity Read ↗

Degeneration of NO-synthesizing cerebrocortical neurons in transgenic mice expressing mutated superoxide dismutase is not due to elevated nitric oxide levels.Semantic proximity Read ↗

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