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Article

Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2000

Detmers P A, Hernandez M, Mudgett J, Hassing H, Burton C, Mundt S, Chun S, Fletcher D, Card D J, Lisnock J, Weikel R, Bergstrom J D, Shevell D E, Hermanowski-Vosatka A, Sparrow C P, Chao Y S, Rader D J, Wright S D, Puré E

Abstract excerpt

Inducible NO synthase (iNOS) present in human atherosclerotic plaques could contribute to the inflammatory process of plaque development. The role of iNOS in atherosclerosis was tested directly by evaluating the development of lesions in atherosclerosis-susceptible apolipoprotein E (apoE)-/- mice that were also deficient in iNOS. ApoE-/- and iNOS-/- mice were cross-bred to produce apoE-/-/iNOS-/- mice and...

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Identifiers

PMID: 10975863
DOI: 10.4049/jimmunol.165.6.3430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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