Article
Impaired vascular function in normoglycemic mice prone to autoimmune diabetes: role of nitric oxide.
European journal of pharmacology - 28 Feb 2007
Traupe Tobias, Nett Philipp C, Frank Beat, Tornillo Luigi, Hofmann-Lehmann Regina, Terracciano Luigi M, Barton Matthias
Abstract excerpt
Type 1 diabetes is an immuno-inflammatory condition which increases the risk of cardiovascular disease, particularly in young adults. This study investigated whether vascular function is altered in mice prone to autoimmune diabetes and whether the nitric oxide (NO)-cyclic GMP axis is involved. Aortic rings suspended in organ chambers and precontracted with phenylephrine were exposed to cumulative concentrations...
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