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Article

Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice.

The Journal of clinical investigation - 1 Aug 2003

Delarasse Cécile, Daubas Philippe, Mars Lennart T, Vizler Csaba, Litzenburger Tobias, Iglesias Antonio, Bauer Jan, Della Gaspera Bruno, Schubart Anna, Decker Laurence, Dimitri Dalia, Roussel Guy, Dierich Andrée, Amor Sandra, Dautigny Andre, Liblau Roland, Pham-Dinh Danielle

Abstract excerpt

We studied the immunological basis for the very potent encephalitogenicity of myelin/oligodendrocyte glycoprotein (MOG), a minor component of myelin in the CNS that is widely used to induce experimental autoimmune encephalomyelitis (EAE). For this purpose, we generated a mutant mouse lacking a functional mog gene. This MOG-deficient mouse presents no clinical or histological abnormalities, permitting us to...

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Share to Encephalomyelitis, Autoimmune, Experimental
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12925695
DOI: 10.1172/JCI15861
PMCID: PMC171383

Genes

MOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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