Article
Inhibition of inducible nitric oxide synthase exacerbates chronic cerebral toxoplasmosis in Toxoplasma gondii-susceptible C57BL/6 mice but does not reactivate the latent disease in T. gondii-resistant BALB/c mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1999
Schlüter D, Deckert-Schlüter M, Lorenz E, Meyer T, Röllinghoff M, Bogdan C
Abstract excerpt
Infection of C57BL/6 mice with Toxoplasma gondii leads to progressive and ultimately fatal chronic Toxoplasma encephalitis (TE). Genetic deletion or inhibition of inducible nitric oxide synthase (iNOS) from the beginning of infection increased the number of T. gondii cysts in the brain and marked...
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