Article
Degeneration of NO-synthesizing cerebrocortical neurons in transgenic mice expressing mutated superoxide dismutase is not due to elevated nitric oxide levels.
Brain research - 16 Jan 1999
Aguila M C, Kuljis R O
Abstract excerpt
Nitric oxide (NO) synthase (NOS)-containing cerebrocortical neurons degenerate in patients with amyotrophic lateral sclerosis (ALS) and dementia, and in transgenic mice expressing a mutated superoxide dismutase gene (G93A) associated with familial ALS. The cerebral cortex of transgenic mice displ...
Topics
- Amino Acid Substitution
- Animals
- Blotting, Western
- Cerebellum
- Cerebral Cortex
- Cyclic GMP
- Disease Models, Animal
- Genotype
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Nerve Degeneration
- Neurons
- Nitric Oxide
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type I
- Polymerase Chain Reaction