Nitric oxide is a potential down-regulating molecule in autoimmune disease: inhibition of nitric oxide production renders PVG rats highly susceptible to EAE.

Abstract excerpt

Rat strains vary in their susceptibility to experimental autoimmune encephalomyelitis (EAE) and in many cases, factors other than MHC antigens are thought to play a role in this. We found that PVG rats, which have a very low susceptibility to EAE, were rendered highly susceptible to clinical dise...

Topics

• Animals
• Cell Division
• Cells, Cultured
• Encephalomyelitis, Autoimmune, Experimental
• Enzyme Inhibitors
• Genetic Predisposition to Disease
• Interferon-gamma
• Lymph Nodes
• Myelin Basic Protein
• Nitrates
• Nitric Oxide
• Nitric Oxide Synthase
• Nitrites
• Rats
• Rats, Inbred Lew
• Rats, Mutant Strains
• Spleen
• omega-N-Methylarginine