Article
RNA recognition by the DNA end-binding Ku heterodimer.
RNA (New York, N.Y.) - 1 Jun 2013
Dalby Andrew B, Goodrich Karen J, Pfingsten Jennifer S, Cech Thomas R
Abstract excerpt
Most nucleic acid-binding proteins selectively bind either DNA or RNA, but not both nucleic acids. The Saccharomyces cerevisiae Ku heterodimer is unusual in that it has two very different biologically relevant binding modes: (1) Ku is a sequence-nonspecific double-stranded DNA end-binding protein with prominent roles in nonhomologous end-joining and telomeric capping, and (2) Ku associates with a specific...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.