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Article

Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 1998

Fan S, Cherney B, Reinhold W, Rucker K, O'Connor P M

Abstract excerpt

In the present study, we report our findings on the impact of p53 disruption on the sensitivity of human cell lines to the antimitotic agents Taxol and vincristine. Comparisons of cell survival and apoptosis were made with y-irradiation and, in some cases, several other DNA-damaging chemotherapeutic agents. Studies in eight Burkitt's lymphoma and lymphoblastoid cell lines (four wild-type p53 and four mutant p53...

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Identifiers

PMID: 9563901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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