Transformed Cells Require Continuous Activity Of RNA Polymerase II To Resist Oncogene-Induced Apoptosis

Abstract excerpt

Studies have indicated that deregulated oncogene expression can result in either programmed cell death or proliferation, depending on the cellular microenvironment. However, little is known about whether oncogenic signals in themselves are able to activate a cellular apoptotic program. We have tested the hypothesis that oncogenic signals in the absence of gene expression are sufficient to induce cell death, which...

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