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Article

The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells.

International journal of cancer - 1 Mar 2012

Ruiz-Magaña María J, Rodríguez-Vargas Jose M, Morales Jorge C, Saldivia Manuel A, Schulze-Osthoff Klaus, Ruiz-Ruiz Carmen

Abstract excerpt

DNA methyltransferase (DNMT)-inhibiting nucleoside analogs reactivate the expression of tumor suppressor genes and apoptosis-related genes silenced by methylation, thus favoring the induction of apoptosis in tumor cells. Moreover, induction of DNA damage seems to contribute to their antitumor effect. However, the apoptotic signaling pathway induced by these demethylating drugs is not well understood. Here, we...

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Identifiers

PMID: 21455989
DOI: 10.1002/ijc.26107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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