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Article

Apoptosis Inhibition by the Human DEK Oncoprotein Involves Interference with p53 Functions

1 Oct 2006

Abstract excerpt

The DEK proto-oncogene has been associated with human carcinogenesis-either as a fusion with the CAN nucleoporin protein or when transcriptionally upregulated. Mechanisms of intracellular DEK functions, however, have remained relatively unexplored. We have recently demonstrated that DEK expression is induced by the high-risk human papillomavirus (HPV) E7 protein in a manner which is dependent upon retinoblastoma...

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PMID: 16894028
DOI: 10.1128/mcb.00430-06

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