Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human papillomavirus type 16 E6 inactivation of p53 in normal human mammary epithelial cells promotes tamoxifen-mediated apoptosis.

Cancer research - 15 Jan 2001

Seewaldt V L, Mrózek K, Dietze E C, Parker M, Caldwell L E

Abstract excerpt

Aberrant p53 expression is frequently observed in mammary epithelial cells obtained from women at high risk for developing breast cancer and is a predictor for the subsequent development of malignancy. Tamoxifen has recently been shown to reduce the incidence of noninvasive breast cancer in high-risk women, but the molecular mechanism of tamoxifen chemoprevention in mammary epithelial tissue that does not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Breast
Share to Cytogenetic Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Recombinant

Share to Estrogens

Share to Oncogene Proteins, Viral

Share to Receptors, Estrogen

Share to Tamoxifen

Source

Identifiers

PMID: 11212259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human papillomavirus type 16 E6 inactivation of p53 in normal human mammary epithelial cells promotes tamoxifen-mediated apoptosis.PMID 11212259Read ↗

E2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell death.Semantic proximity Read ↗

Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cellsSemantic proximity Read ↗

<i>p53</i> Loss Synergizes with Estrogen and Papillomaviral Oncogenes to Induce Cervical and Breast CancersSemantic proximity Read ↗

Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.Semantic proximity Read ↗

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cellsSemantic proximity Read ↗

Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells.Semantic proximity Read ↗

Multiple Functions of Human Papillomavirus Type 16 E6 Contribute to the Immortalization of Mammary Epithelial CellsSemantic proximity Read ↗

Apoptosis in human papillomavirus16 E7-, but not E6-immortalized human uroepithelial cells.Semantic proximity Read ↗

Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytesSemantic proximity Read ↗

Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: Repression ofE6/E7-oncogene expression and induction of apoptosisSemantic proximity Read ↗

Requirement of wild-type p53 protein for maintenance of chromosomal integritySemantic proximity Read ↗

Endogenous Human Papillomavirus E6 and E7 Proteins Differentially Regulate Proliferation, Senescence, and Apoptosis in HeLa Cervical Carcinoma CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.