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Article

Temozolomide induces senescence but not apoptosis in human melanoma cells

30 Oct 2007

Abstract excerpt

Temozolomide (TMZ), a DNA alkylating agent used in the treatment of melanoma, is believed to mediate its effect by addition of a methyl group to the O(6) position of guanine in DNA. Resistance to the agent may be in part due to the activity of O(6)-methylguanine-DNA methyl transferase (MGMT). In the present study, we show that sensitivity of melanoma cells to TMZ was dependent on their p53 status and levels of...

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Share to DNA Repair Mechanisms
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PMID: 17968428
DOI: 10.1038/sj.bjc.6604017

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